Actives extractives

PEARfect Tone®

Biomimetic multispectrum defense for skin protection & tone evening

 

UV & IR Defense – Skin Brightening – Tone Evening

INCI name

Glycerin, Pyrus Communis (Pear) Fruit Extract

 

 
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UV RADIATION DAMAGES

Exposure to ultraviolet (UV) and infrared (IR) radiation accelerates skin aging, particularly in the most exposed areas. This process, known as photoaging, results from prolonged exposure to natural and artificial sources.

UVA, UVB, and UVC rays contribute to photoaging by triggering hyperpigmentation, uneven texture, loss of elasticity, and wrinkles often due to melanin production triggered by melanogenesis and tyrosinase activation (Lipeng Wu et al., 2022). Simultaneously, infrared radiation (IR) generates heat stress (burns and urticaria), intensifying collagen degradation, and inflammation, leading to deeper tissue damage (Horton L. et al., 2023).

Conventional treatments, such as laser therapy, chemical peels, and topical medications, can manage photodamage but not fully reverse it.

What if photoaging could be prevented?

PEAR STRATEGIES TO FIGHT UV RADIATIONS DAMAGES

Plants have evolved sophisticated defenses against radiation, producing flavonoids and polyphenols as natural sunscreens and antioxidants.
 
Pears naturally accumulate flavonoids in the skin to block UV rays while their waxy cuticle reflects sunlight. Inside, they generate antioxidants that combat oxidative stress. By neutralizing free radicals, they help modulate Heat Shock Proteins (HSPs), reducing thermal stress, maintaining hydration, and preventing premature aging thus ensuring comprehensive protection across the light spectrum.
 
This synergy of biochemical, structural, and molecular strategies effectively mitigates the impact of radiation.
 
Inspired by this biomimetic approach, we developed PEARfect Tone®, an advanced ingredient for broad-spectrum protection against UV and IR radiation.

THE SCIENCE BEHIND

PEARfect Tone® is formulated with Pyrus communis fruit extract derived from the Xuehua pear, naturally rich in flavonoid and polyphenols, through ultrasound-assisted extraction and tangential flow filtration – a sustainable and innovative process removing waste substances such as fibers and debris.

PEARfect Tone® harnesses the power of dihydromyricetin, a UV absorber and tyrosinase inhibitor, combined with arbutin, known for its skin-brightening effect against hyperpigmentation.Additionally, its high antioxidant content enhances overall skin protection.

To assess PEARfect Tone® protective and restorative properties, its efficacy has been evaluated on:

  • Reconstructed human epidermis model mimicking the highly differentiated human skin, which has been exposed to UVA/UVB radiation (50 mJ/cm² UVB / 1 J/cm² UVA).
  • Human keratinocytes subjected to photo-thermal stress (environmental temperature above 42 °C and a total exposure of 300 J/m2 energy).

HYPERPIGMENTATION INHIBITION

PEARfect Tone®, in human epidermis, significantly (p<0.05) reduces melanin production after UV exposure in a dose-dependent manner (Graph 1) and its activity is driven by the tyrosinase inhibition whom enzymatic activity, responsible of melanin synthesis, has been inhibited after 1 hour treatment at any concentrations tested (Graph 2). Pictures of melanin production in human epidermidis (represented by brown color intensity) after UV exposure and PEARfect Tone® treatment are shown for each samples. The browner the epitelium becomes, the more melanin and radiation-induced damage increase. 

Protection against IR-induced skin stress

PEARfect Tone®, in human keratinocytes subjected to photo-thermal stress (environmental temperature above 42 °C and a total exposure of 300 J/m2 energy) significantly (p<0.05) reduces the stress marker HSP72 levels in a dose-dependent manner demonstrating a protective efficacy towards damage agents as IR radiation.

Bar chart showing the reduction of HSP72 expression in human keratinocytes after treatment with PEARfect Tone® at different concentrations, demonstrating anti-photoaging and IR protection.

RADIATION IMPACT ON SKIN

  1. Accelerates skin aging of the most exposed areas affecting all skin types.
  2. Leads to hyperpigmentation, texture changes, loss of elasticity, wrinkles, and redness by stimulating melanin production.
  3. Treatments can reduce signs of photodamage without fully erasing them.

PYRUS COMMUNIS STRATEGIES

  1. Has evolved complex defenses producing protective molecules that act as natural sunscreens.
  2. Accumulates flavonoids in the skin to block UV rays and the waxy cuticle reflects sunlight.
  3. Combines biochemical, structural, and molecular strategies to protect from radiation damage, generating antioxidants for complete protection.

Pearfect tone®: A BIOMIMETIC SOLUTION

  1. Rich in flavonoids, reduces hyperpigmentation.
  2. Inhibits tyrosinase activity diminishing melanin after UV exposure.
  3. Reduces heat shock response to photo-thermal stress, neutralizing free radicals, and maintaining hydration.

Hair and scalp protection from UV radiations

Flavonoids are powerful antioxidants also for hair.

They have been shown to play a protective role in maintaining hair health by protecting it from UV-induced damage (Cižmárová B. et al., 2023; Bassino E. et al., 2020).

Flavonoids can reach the hair cortex, inhibit the formation of hair-derived radicals upon irradiation, and protect internal hair structures from oxidation thereby preserving the structural integrity of hair and preventing premature degradation (Dario M.F. et al., 2020).

  • Multispectrum Protection: PEARfect Tone® provides natural defense against UV and IR radiation, reducing oxidative and thermal stress through flavonoids like dihydromyricetin and the brightening agent arbutin.
  • Anti-Photoaging Action: Significantly lowers HSP72 expression and melanin production under photo-thermal stress, helping prevent signs of photoaging such as wrinkles, dark spots, and dehydration.
  • Brightening & Even Tone: Inhibits tyrosinase activity and reduces melanin synthesis, visibly improving skin tone uniformity after UV exposure.
  • Biomimetic Innovation: Inspired by the natural defense mechanisms of Pyrus communis, this active replicates the pear’s antioxidant-rich strategy to protect and restore skin.
  • Eco-Conscious & Skin-Friendly: Biodegradable, non-irritating, and respectful of aquatic ecosystems, PEARfect Tone® aligns with modern sustainability and safety standards.

ORIGIN

Plant extraction

 
   Appearance Clear Liquid
   Colour Light yellow
   Odour Characteristic
   pH 3.5 – 6.5
   Dry residue (105°C) >95%
   Specific Gravity (25°C) 1.2 – 1.3

Ideal for emulsions or transparent water-based formulations

% OF USE: 2.0 – 5.0%

 

 

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