actives

multi FEEL®

Soothing – antiredness – moisturizing plant-based complex

soothing – antiredness – moisturizing

INCI name

Polyglycerin-6, Aqua, Propanediol, Centella Asiatica Leaf Extract, Scutellaria Baicalensis Root Extract, Hylocereus Undatus Fruit Extract, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root Extract, Berberis Vulgaris Root Extract, Rosmarinus Officinalis Leaf Extract

 

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Multi FEEL® is a blend of plant extracts that shields skin from inflammation, oxidative stress, and aging. It alleviates redness and itching, promoting a balanced, healthy skin appearance. This blend also enhances skin defense against external aggressions and offers a safe, effective alternative to soothing solutions and steroids for dermatitis treatment. Its efficacy is rapid yet gentle, suitable for treating insect bites, sunburns, and can be integrated into skincare and haircare products to reduce their aggressiveness.

COMPOSITION

  1. Hylocereus Undatus Fruit Extract: Rich in antioxidants and micronutrients; offers photoprotection and aids in skin wound healing by promoting type III collagen production.

  2. Rosmarinus Officinalis Extract: Contains phytocompounds with antioxidant, anti-inflammatory, oxidative stress control, atherosclerosis prevention, and antimicrobial properties.

  3. Glycyrrhiza Glabra Extract: Comprises flavonoids, amides, vitamins, and acids; treats dermatitis, pruritus, acne, sunburn effects, and has antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and antidiabetic properties.

  4. Centella Asiatica Extract: Contains terpenoids and acids; offers antioxidant, anti-inflammatory, antimicrobial, anticarcinogenic activities, and is used for treating wounds, burns, psoriasis, and scleroderma.

  5. Camellia Sinensis Extract: Rich in polyphenols and flavonols; provides antioxidant, photoprotective, anticellulite, slimming properties, and improves skin microcirculation and anti-inflammatory activity.

  6. Scutellaria Baicalensis Extract: Traditionally used for inflammatory and allergic diseases; exhibits antioxidant, anti-inflammatory, UV-protection, and atopic dermatitis treatment properties.

  7. Berberis Vulgaris Extract: Offers antimicrobial, anti-acne, anti-diabetic effects; contains organic acids and alkaloids like berberine, beneficial for antioxidants, anti-aging, anti-inflammatory, and anti-cancer effects.

Decrease of IL-8 and tnf-alpha production

Skin diseases are often linked to a pro-inflammatory state. For example, IL-8 is related to the severity of atopic dermatitis (Murata S. et al., 2021) and TNF-α is the master cytokine regulator in psoriasis or contact dermatitis (Banno T., et al. 2004). 
 
Given the anti-inflammatory ability of multi FEEL® extracts, we evaluated the in vitro production of both IL-8 and TNF-α on LPS-stimulated keratinocytes treated with different doses of multi FEEL®. 
 
We found that 1.0% and 1.5% multi FEEL® significantly decreases of IL-8 and TNF-α production in keratinocytes stimulated with LPS. (**p<0.01)
Bar charts showing the effect of different concentrations of multi FEEL® on IL-8 and TNF-α levels in LPS-induced inflammation.

Decrease of IL-8 and tnf-alpha production

This in vivo study shows multi FEEL® efficacy on subjects with hands irritative dermatitis. Daily application of 2% multi FEEL® significantly increases hydration and improves TEWL (Trans Epidermal Water Loss) as well as erythema. In particular, LONG-TERM efficacy proves the beneficial effects of multi FEEL® functional ingredients.

Bar charts showing the effects of treatment on skin hydration, TEWL, and erythema measurements over time (T0, 1H, 1W, 2W).

antioxidant efficacy

multi FEEL® is a source of natural anti-oxidants. For this reason, we evaluated its efficacy in preventing the formation of reactive oxygen species (ROS), mainly responsible of skin aging. 
 
We found that 0.17% and 0.5% multi FEEL® (TS) significantly reduced ROS after 2 and 4 minutes of UV exposure and 1.5% multi FEEL® for all times of UV exposure.
Bar chart showing the effect of different concentrations of TS on ROS production under UV exposure for varying time durations (2, 4, 6, 8, and 10 minutes).

SOOTHING EFFECT AFTER IRRITATION STIMULUS

multi FEEL® reduces SDS-induced erythema proving its SHORT-TERM (after a single application) efficacy.
 

ORIGIN

Synergistic blend of vegetal active compounds delivered in polyglycerol medium.

   Appearance Liquid
   Colour Yellow
   Odour Characteristic
   pH 4.5 – 6.5
   Dry residue (105°C) 55 ÷ 65 %
   Specific Gravity (25°C)
1.165 – 1.185 

Specifically designed to soothe atopic dermatitis, in OW and WO babycare emulsions.

% OF USE:
1.0 – 2.0% to improve overall formula’s dermocompatibility
3.0 % to treat atopic dermatitis and irritated skins

 

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